Dr. Martin Harris (Liam Neeson) and his wife Liz (January Jones) arrive in Berlin for a biotechnology summit. Upon arriving at their hotel, Martin realizes he forgot his briefcase at the airport. He takes a taxicab driven by Gina (Diane Kruger), but on the way to the airport, the cab crashes off a bridge into the river after narrowly avoiding a refrigerator that falls off a delivery truck in front of them. Martin is knocked unconscious upon impact, but Gina saves him from drowning before fleeing from the scene. On Thanksgiving day, he comes to at the hospital after being in a coma for four days.